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VITT is a potential complication of ChAdOx1‐nCov‐19 vaccination — early recognition is key to improved outcomes A syndrome of thrombosis and thrombocytopenia has been described in a small proportion of patients vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). The thrombosis can be severe and, on occasion, fatal.

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Qualifying Criteria for Ig Therapy. Suspected or confirmed diagnosis of vaccine induced immune thrombotic thrombocytopenia (VITT) Review Criteria for Assessing the Effectiveness of Ig Use. Review is not mandated for this indication however the following criteria may be useful in assessing the effectiveness of therapy.


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VITT is less likely if the platelet count is >x/L, but D-dimers are elevated or fibrinogen is reduced. VITT is much less likely if the platelet count is stable and >x/L, D-dimers are not elevated AND fibrinogen is normal. Patients can be treated as non-VITT thrombosis.


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Vaccine-induced immune thrombocytopenia and thrombosis (VITT) is a new syndrome associated with the ChAdOx1 nCoV adenoviral vector vaccine against severe acute respiratory syndrome.
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      VITT should be considered when patients present at day 4–28 after vaccination with unusual site thrombosis: splanchnic and/or central venous sinus thrombosis, or thrombocytopenia (or falling platelets) and markedly elevated D‐dimer.

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  • The risk of death and serious outcomes of COVID (including thrombosis) far outweigh the small risk of VITT. Who is at risk for VITT? Early data suggest that VITT occurs only following a COVID vaccination with Johnson & Johnson or AstraZeneca vaccine. Note that AstraZeneca vaccine is NOT available in the United States.

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    Second Doses of Covid Vaccine in Patients Who Had VITT after a First Dose of ChAdOx1 nCoV To determine the risk of a second Covid vaccine dose in these patients with vaccine-induced.
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    When should I suspect TTS/VIPIT/VATT/VITT? The Thrombosis and Haemostasis society of Australia and New Zealand (THANZ) has released a statement which will be updated as more evidence becomes available. THANZ summarises the features of TTS/VIPIT/VATT/VITT (as of 29 June ) as: • Onset days after vaccination.


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